Cancer Letters
Volume 210, Issue 1 , Pages 1-6, 8 July 2004

Antiproliferative crude soy saponin extract modulates the expression of IκBα, protein kinase C, and cyclooxygenase-2 in human colon cancer cells

  • Hwa-Young Kim

      Affiliations

    • Department of Food and Nutrition, Sookmyung Women's University, 53-12 Chungpa-Dong, 2-ka, Yongsan-ku, Seoul 140-742, South Korea
    • ,
  • Rina Yu

      Affiliations

    • Department of Food and Nutrition, University of Ulsan, Ulsan, South Korea
    • ,
  • Jeong-Sang Kim

      Affiliations

    • Department of Animal Science and Biotechnology, Kyungpook National University, Daegu, South Korea
    • ,
  • Young-Kyoon Kim

      Affiliations

    • Department of Forestry Products, Kookmin University, Seoul, South Korea
    • ,
  • Mi-Kyung Sung

      Affiliations

    • Department of Food and Nutrition, Sookmyung Women's University, 53-12 Chungpa-Dong, 2-ka, Yongsan-ku, Seoul 140-742, South Korea
    • Corresponding Author InformationCorresponding author. Tel./fax.: +82-2-710-9395

Received 5 September 2003; received in revised form 21 October 2003; accepted 12 January 2004.

Abstract 

Frequent consumption of soy and soy-based products is associated with reduced cancer incidence particularly for breast, colon, and prostate cancer. In this study, we examined the effect of crude soy saponin extract on PMA (phorbol 12-myristate 13-acetate)-induced inflammatory responses. Human adenocarinoma cells (HT-29) were treated with various concentrations of saponin extract for 72 h. Cell growth was measured at 24, 48 and 72 h of incubation, and the PMA-induced expressions of cyclooxygenase-2 (COX-2), protein kinase C (PKC), and IκBα were determined. The results indicate that crude saponin extract decreased cell growth in a dose- and time-dependent manner. Crude soy saponin extract suppressed the degradation of IκBα in PMA-stimulated cells, while COX-2 and PKC expressions were significantly down-regulated. These findings support the hypothesis that the soy saponins reduce the risk of colon tumorigenesis possibly by suppressing inflammatory responses.

Keywords:  Soybean saponins, Colon cancer, Inflammation, IκBα, Protein kinase C, Cyclooxygenase-2

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PII: S0304-3835(04)00054-0

doi:10.1016/j.canlet.2004.01.009

Cancer Letters
Volume 210, Issue 1 , Pages 1-6, 8 July 2004

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