Cancer Letters
Volume 210, Issue 1 , Pages 111-118, 8 July 2004

Expression of cell cycle-related gene products in different forms of primary versus recurrent PVNS

  • Helgard Weckauf

      Affiliations

    • Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Address: Pathologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany. Tel.: +49-0-6221-562609; fax: +49-0-6221-565251
    • ,
  • Birgit Helmchen

      Affiliations

    • Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany
    • ,
  • Ulf Hinz

      Affiliations

    • Department of Surgery, Ruprecht-Karls-University, Heidelberg, Germany
    • ,
  • Carola Meyer-Scholten

      Affiliations

    • Centre of Rheuma-Pathology, WHO-collaborating Center, Mainz, Germany
    • ,
  • Sebastian Aulmann

      Affiliations

    • Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany
    • ,
  • Herwart F Otto

      Affiliations

    • Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany
    • ,
  • Irina Berger

      Affiliations

    • Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany

Received 28 October 2003; received in revised form 10 January 2004; accepted 15 January 2004.

Abstract 

Expression patterns of cell cycle regulating gene products and Ki-67 in proliferating synovial cells of primary and recurrent pigmented villonodular synovitis (PVNS) in localized and diffuse lesions were examined by immunohistochemistry. Alterations of cell cycle-related proteins were seen in 98.7% of analyzed lesions. Both RB- and p53 pathways play a role in cell cycle dysregulation in PVNS. The RB pathway was more frequently altered in primary disease, while alterations of the p53 pathway seemed to be more important in recurrent lesions, regardless of the histomorphological type of disease. Ki-67 proliferation rate was elevated in recurrent tumors.

Keywords:  Pigmented villonodular synovitis, Cell cycle, Tissue microarray

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PII: S0304-3835(04)00051-5

doi:10.1016/j.canlet.2004.01.013

Cancer Letters
Volume 210, Issue 1 , Pages 111-118, 8 July 2004

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