Cancer Letters
Volume 208, Issue 1 , Pages 89-94 , 10 May 2004

1,2,3,4,6-Penta-O-galloyl-beta-d-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor

  • Sung-Jin Lee

      Affiliations

    • Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, South Korea
    • ,
  • Hwan Myung Lee

      Affiliations

    • Graduate School of East-West Medical Science, Kyung Hee University, Yong In 449-701, South Korea
    • ,
  • Seung-Taek Ji

      Affiliations

    • Bioinfomatix Inc., 1424-2, Sungwoo Bldg., Seocho-Dong, Seoul 137-070, South Korea
    • ,
  • Seung-Rock Lee

      Affiliations

    • Center for Cell Signaling Research, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, South Korea
    • ,
  • Woongchon Mar

      Affiliations

    • Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 110-460, South Korea
    • ,
  • Yong Song Gho

      Affiliations

    • Graduate School of East-West Medical Science, Kyung Hee University, Yong In 449-701, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-312012178; fax: +82-312048119

Received 26 September 2003 ,Revised 4 November 2003 ,Accepted 6 November 2003.

References 

  1. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249–257
  2. Carmeliet P. Angiogenesis in health and disease. Nat. Med. 2003;9:653–660
  3. Zetter BR. Angiogenesis and tumor metastasis. Annu. Rev. Med. 1998;49:407–424
  4. Boehm-Viswanathan T. Is angiogenesis inhibition the Holy Grail of cancer therapy?. Curr. Opin. Oncol. 2000;12:89–94
  5. Gospodarowicz D, Abraham JA, Schilling J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc. Natl Acad. Sci. USA. 1989;86:7311–7315
  6. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Frrarara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246:1306–1309
  7. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, et al. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993;72:835–846
  8. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992;255:989–991
  9. Shalaby F, Rossant J, Yamaguch T, Gertsenstein M, Wu XF, Breitman ML, et al. Failure of blood-island formation vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62–66
  10. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380:435–439
  11. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, et al.  Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996;380:439–442
  12. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993;362:841–844
  13. Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature. 1994;367:576–579
  14. Goldman CK, Kendall RI, Cabrera G, Soroceanu L, Heike Y, Gillespie GY, et al.  Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate. Proc. Natl Acad. Sci. USA. 1998;95:8795–8800
  15. Kim YM, Hwang S, Kim YM, Pyun BJ, Kim TY, Lee ST, et al.  Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1. J. Biol. Chem. 2002;277:27872–27879
  16. Bae DG, Gho YS, Yoon WH, Chae CB. Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis. J. Biol. Chem. 2000;275:13588–13596
  17. Lamy S, Gingras D, Beliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 2002;62:381–385
  18. Kondo T, Ohta T, Igura K, Hara Y, Kaji K. Tea catechins inhibit angiogenesis in vitro, measured by human endothelial cell growth, migration and tube formation, through inhibition of VEGF receptor binding. Cancer Lett. 2002;180:139–144
  19. Martiny-Baron G, Marme D. VEGF-mediated tumour angiogenesis: a new target for cancer therapy. Curr. Opin. Biotechnol. 1995;6:675–680
  20. Veikkola T, Alitalo K. VEGFs, receptors and angiogenesis, Semin. Cancer Biol. 1999;9:211–220
  21. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer. 2002;2:795–803
  22. Kim CW, Lee HM, Lee TH, Kang C, Kleinman HK, Gho YS. Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin. Cancer Res. 2002;62:6312–6317
  23. Oh GS, Pae HO, Oh H, Hong SG, Kim IK, Chai KY, et al.  In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-d-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells. Cancer Lett. 2001;174:17–24
  24. Wroblewski K, Muhandiram R, Chakrabartty A, Bennick A. The molecular interaction of human salivary histatins with polyphenolic compounds. Eur. J. Biochem. 2001;268:4384–4397
  25. Miyamoto K, Kishi N, Koshiura R, Yoshida T, Hatano T, Okuda T. Relationship between the structures and the antitumor activities of tannins. Chem. Pharm. Bull. 1987;35:814–822
  26. Bhimani RS, Troll W, Grunberger D, Frenkel K. Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res. 1993;53:4528–4533
  27. Pan MH, Lin JH, Lin-Shiau SY, Lin JK. Induction of apoptosis by penta-O-galloyl-beta-d-glucose through activation of caspase-3 in human leukemia HL-60 cells. Eur. J. Pharmacol. 1999;381:171–183

PII: S0304-3835(03)00782-1

doi: 10.1016/j.canlet.2003.11.008

Cancer Letters
Volume 208, Issue 1 , Pages 89-94 , 10 May 2004

Article Tools

* Image Usage & Resolution