Cancer Letters
Volume 205, Issue 2 , Pages 197-205 , 18 March 2004

The truncation of Ku86 in human lymphocytes

References 

  1. Zhou B-BS, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature. 2000;408:433–439
  2. Smith GCM, Jackson SP. The DNA-dependent protein kinase. Genes Dev. 1999;13:916–934
  3. Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S, Homma M. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis scleroderma overlap. J. Clin. Invest. 1981;68:611–620
  4. Wu X, Lieber MR. Protein–protein and protein–DNA interaction regions within the DNA end-binding protein Ku70–Ku86. Mol. Cell. Biol. 1996;16:5186–5193
  5. Cao QP, Pitt S, Leszyk J, Baril EF. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. Biochemistry. 1994;33:8548–8557
  6. Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, et al.  Human DNA helicase II a novel DNA unwinding enzyme identified as the Ku autoantigen. Eur. Mol. Biol. Org. J. 1994;13:4991–5001
  7. Willis DM, Loewy AP, Charlton-Kachigian N, Shao JS, Ornitz DM, Towler DA. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. J. Biol. Chem. 2002;277:37280–37291
  8. Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, et al.  Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Natl Acad. Sci. USA. 2000;97:2668–2673
  9. Gottlieb TM, Jackson SP. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell. 1993;72:131–142
  10. Wang J, Dong X, Reeves WH. A model for Ku heterodimer assembly and interaction with DNA. J. Biol. Chem. 1998;273:31068–31074
  11. Hsu H-L, Gilley D, Galande SA, Hande MP, Allen B, Kim S-H, et al.  Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 2000;14:2807–2812
  12. Mirio T, Hanissian SH, Bacharier LB, Teraoka H, Nonoyama S, Seki M, et al.  Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999;11:339–348
  13. Sawada M, Hayes P, Matsuyama S. Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70. Nat. Cell Biol. 2003;5:352–357
  14. Han Z, Johnston C, Reeves WH, Carter T, Wyche JH, Hendrickson EA. Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity. J. Biol. Chem. 1996;271:14098–14104
  15. Muller C, Dusseau C, Calsou P, Salles B. Human normal peripheral blood B-lymphocytes are deficient in DNA-dependent protein kinase activity due to the expression of a variant form of the Ku86 protein. Oncogene. 1998;16:1553–1560
  16. Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA. The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Mol. Cell. Biol. 1999;19:3267–3277
  17. Tai YT, Teoh G, Lin B, Davies FE, Chauchan D, Treon SP, et al.  Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage. J. Immunol. 2000;165:6347–6355
  18. Jeng YW, Chao HC, Chiu CF, Chou WG. Senescent human fibroblasts have elevated Ku86 proteolytic cleavage activity. Mutat. Res. 1999;435:225–232
  19. Sallmyr A, Du L, Bredberg A. An inducible Ku86-degrading serine protease in human cells. Biochim. Biophys. Acta. 2002;1593:57–68
  20. Łanuszewska J, Cudak A, Rzeszowska-Wolny J, Widlak P. Detection of damage-recognition proteins from human lymphocytes. Acta Biochim. Pol. 2000;47:443–450
  21. Widlak P, Łanuszewska J, Cary RB, Garrard WT. Subunit structures and stoichiometries of human DFF proteins before and after induction of apoptosis. J. Biol. Chem. 2003;278:26915–26922
  22. Green M, Low J, Harcourt SA, Akinluyi P, Row T, Cole J, et al.  UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and Xeroderma pigmentosum donors in the comet assay: a potential diagnostic technique. Mutat. Res. 1992;273:137–144
  23. Collins A, Fleming I, Gedik C. In vitro repair of oxidative and ultraviolet-induced DNA damage in supercoiled nucleoid DNA by human cell extract. Biochem. Biophys. Acta. 1994;1219:724–727
  24. Koike M, Ikuta T, Miyasaka T, Shiomi T. Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal. Oncogene. 1999;18:7495–7505
  25. D'Amours D, Sallmann FR, Dixit VM, Poirier GG. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J. Cell. Sci. 2001;114:3771–3778

PII: S0304-3835(03)00713-4

doi: 10.1016/j.canlet.2003.10.016

Cancer Letters
Volume 205, Issue 2 , Pages 197-205 , 18 March 2004

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