Cancer Letters
Volume 208, Issue 1 , Pages 81-88 , 10 May 2004

Gene dose mapping delineated boundaries of a large germline deletion responsible for multiple endocrine neoplasia type 1

  • Mariko Kikuchi

      Affiliations

    • Tumor Endocrinology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    • Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    • ,
  • Naganari Ohkura

      Affiliations

    • Tumor Endocrinology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    • ,
  • Ken Yamaguchi

      Affiliations

    • Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    • ,
  • Takao Obara

      Affiliations

    • Department of Endocrine Surgery, Tokyo Women's Medical University, Tokyo, Japan
    • ,
  • Toshihiko Tsukada

      Affiliations

    • Tumor Endocrinology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3542-2511x4305; fax: +81-3-3542-8170

Received 7 October 2003 ,Accepted 7 October 2003.

References 

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  2. Trump D, Farren B, Wooding C, Pang JT, Besser GM, Buchanan KD, et al.  Clinical studies of multiple endocrine neoplasia type 1 (MEN1). Q. J. Med. 1996;89:653–669
  3. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi S-E, Collins FS, Emmert-Buck MR, et al.  Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276:404–407
  4. Agarwal SK, Kester MB, Debelenko LV, Heppner C, Emmert-Buck MR, Skarulis MC, et al.  Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum. Mol. Genet. 1997;6:1169–1175
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  9. Kishi M, Tsukada T, Shimizu S, Futami H, Ito Y, Kanbe M, et al. A large germline deletion of the MEN1 gene in a family with multiple endocrine neoplasia type 1. Jpn J. Cancer Res. 1998;89:1–5
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  11. Celi FS, Cohen MM, Antonarakiss SE, Wertheimer E, Roth J, Shuldiner AR. Determination of gene dosage by a quantitative adaptation of the polymerase chain reaction (gd-PCR): rapid detection of deletions and duplications of gene sequences. Genomics. 1994;21:304–310
  12. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, et al.  Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science. 1991;253:665–669
  13. Katz P, Whalen G, Kehrl JH. Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. J. Biol. Chem. 1994;269:16802–16809
  14. Guru SC, Olufemi S-E, Manickam P, Cummings C, Gieser LM, Pike BL, et al.  A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13. Genomics. 1997;42:436–445
  15. Nicolaides NC, Chang S-Y, Aaltonen LA, Moisio A-L. Founding mutations and Alu-mediated recombination in hereditary colon cancer. Nat. Med. 1995;1:1203–1206

PII: S0304-3835(03)00709-2

doi: 10.1016/j.canlet.2003.10.011

Cancer Letters
Volume 208, Issue 1 , Pages 81-88 , 10 May 2004

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