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Cancer Letters
Volume 206, Issue 2
, Pages 193-199
, 8 April 2004
The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer
References
- . NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 1998;16:225–260
- . Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene. 1999;18:6925–6937
- . Missing pieces in the NF-kappaB puzzle. Cell. 2002;109(Suppl):S81–S96
- . Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 2000;18:621–663
- The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 1999;189:1839–1845
- . RelB cellular regulation and transcriptional activity are regulated by p100. J. Biol. Chem. 2002;277:1405–1418
- Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001;293:1495–1499
- . Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer Lett. 2002;181:1–9
-
.
Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.
Eur. Mol. Biol. Org. J. 2001;20:6805–6815
- . The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription. Semin. Cancer Biol. 1997;8:121–129
- . Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 1997;272:24113–24116
- . A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev. 1998;12:968–981
- . Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 1997;11:463–475
- . Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases. J. Biol. Chem. 1998;273:12779–12785
- . NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer. 2002;2:301–310
- . NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 1999;19:2690–2698
- . NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 1999;19:5785–5799
- . NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 1999;401:86–90
- . Members of the nuclear factor kappa B family transactivate the murine c-myb gene. J. Biol. Chem. 1995;270:7661–7671
- . Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B. J. Biol. Chem. 1992;267:16288–16291
- . Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science. 1997;275:523–527
- . INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB. Oncogene. 1999;18:2663–2666
- . Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001;411:1017–1021
- . IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001;107:763–775
- . NF-kappaB at the crossroads of life and death. Nat. Immunol. 2002;3:221–227
- . Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell. 1991;65:1191–1201
-
.
p53 Stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy.
Cancer Cell. 2002;1:493–503
- . NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J. Biol. Chem. 1997;272:15174–15183
- NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene. 2003;22:90–97
- . Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999;18:6853–6866
-
.
Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms.
Proc. Natl. Acad. Sci. USA. 1998;95:13012–13017
- . TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science. 1996;274:784–787
- . Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 1999;5:412–417
- . Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothe cin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation. Cancer Res. 2000;60:2323–2330
- . Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis. Ann. Thorac. Surg. 2000;70:930–936 discussion 936–937
- . Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin. Oncogene. 2001;20:859–868
- . Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 2001;107:241–246
- Genomic organization of human and mouse genes for vascular endothelial growth factor C. J. Biol. Chem. 1997;272:25176–25183
- IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program. J. Biol. Chem. 2002;277:45129–45140
- . Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. J. Virol. 1999;73:5548–5555
- . Nuclear factor kappaB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts. Biochem. Biophys. Res. Commun. 1999;264:561–567
- . Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res. 2000;60:6557–6562
- . Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev. 1999;18:345–357
- . Redox signaling in macrophages. Mol. Aspects Med. 2001;22:189–216
- . Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer. 2002;2:28–37
- Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398–402
- . Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology. 1997;113:1099–1109
- . Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB. Scand. J. Gastroenterol. 2001;36:706–716
- . Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 1997;336:1066–1071
- . Increased risk of large-bowel cancer in Crohn's disease with colonic involvement. Lancet. 1990;336:357–359
- . Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 1996;2:998–1004
- Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology. 1998;115:357–369
- Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease. Br. J. Pharmacol. 1998;124:431–433
- . Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263–274
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 1996;98:1010–1020
- . Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization. Ann. N. Y. Acad. Sci. 2002;973:392–395
- . Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 1998;101:1163–1174
- . Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000;119:1209–1218
- Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J. Biol. Chem. 1999;274:26448–26453
- . Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J. Immunol. 2001;167:2911–2920
- Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev. 1998;7:97–102
- . Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int. J. Cancer. 1999;82:473–476
- . The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 1998;396:77–80
- . Sulindac inhibits activation of the NF-kappaB pathway. J. Biol. Chem. 1999;274:27307–27314
- . Proteasome inhibition: a novel approach to cancer therapy. Trends Mol. Med. 2002;8:S49–S54
- . NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach. Semin. Cancer Biol. 2003;13:15–28
- . Proteasome inhibition in cancer: development of PS-341. Semin. Oncol. 2001;28:613–619
- . NF-kappaB: arresting a major culprit in cancer. Drug Discov. Today. 2002;7:653–663
PII: S0304-3835(03)00629-3
doi: 10.1016/j.canlet.2003.08.029
© 2003 Elsevier Ireland Ltd. All rights reserved.
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Cancer Letters
Volume 206, Issue 2
, Pages 193-199
, 8 April 2004
