Cancer Letters
Volume 203, Issue 2 , Pages 171-180, January 2004

Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin–platinum(II) conjugates

  • Christian Lottner

      Affiliations

    • Institute of Inorganic Chemistry, University of Regensburg, Regensburg 93040, Germany
    • Institute of Pathology, University of Regensburg, Regensburg 93042, Germany
    • Corresponding Author InformationCorresponding author. Address: Institute of Pathology, University of Regensburg, Regensburg 93042, Germany. Tel.: +49-941-943-6640; fax: +49-941-943-6602
    • ,
  • Ruth Knuechel

      Affiliations

    • Institute of Pathology, University of Regensburg, Regensburg 93042, Germany
    • ,
  • Guenther Bernhardt

      Affiliations

    • Institute of Pharmacy, University of Regensburg, Regensburg 93040, Germany
    • ,
  • Henri Brunner

      Affiliations

    • Institute of Inorganic Chemistry, University of Regensburg, Regensburg 93040, Germany

Received 16 May 2003; received in revised form 8 September 2003; accepted 8 September 2003.

Abstract 

Four porphyrin–platinum complexes, conceived as a new approach in cancer therapy by combining the cytostatic activity of cisplatin or oxaliplatin and the photodynamic effect of hematoporphyrin in the same molecule, were studied in detail with respect to solubility and stability in cell culture medium as well as in terms of cytotoxicity and phototoxicity against J82 bladder cancer cells and UROtsa, normal urothelial cells. This study demonstrated that the most active and promising compound among the porphyrin–platinum conjugates investigated was the water-soluble porphyrin–platinum complex 4 (diammine{7,12-bis[1-(polyethyleneglycol-750-monomethylether-1-yl)ethyl]-3,8,13,17-tetramethylporphyrin-2,18-dipropionato}platinum(II)) which exhibited a synergistic antiproliferative effect compared to cisplatin and hematoporphyrin alone or a combination of the drugs.

Keywords: Porphyrin–platinum conjugates, Bladder cancer, Photodynamic therapy, Chemotherapy, Synergistic effect

Abbreviations: AAS, atomic absorption spectroscopy, M-VAC, methotrexate, vinblastine, doxorubicin, cisplatin, PDT, photodynamic therapy, PEG, polyethyleneglycol, DMF, N,N-dimethylformamide

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PII: S0304-3835(03)00593-7

doi:10.1016/j.canlet.2003.09.001

Cancer Letters
Volume 203, Issue 2 , Pages 171-180, January 2004

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