« Previous
Next »
Cancer Letters
Volume 198, Issue 1
, Pages 1-20
, 30 July 2003
Metastasis suppressor pathways—an evolving paradigm
References
-
.
Metastasis: lymphangiogenesis and cancer metastasis.
Nature Rev. Cancer. 2002;2:573–583
-
.
Metastasis suppressors alter the signal transduction of cancer cells.
Nature Rev. Cancer. 2003;3:55–63
-
.
Implications of tumor progression on clinical oncology.
Clin. Exptl. Metastasis. 1985;3:151–188
- . The clonal evolution of tumor cell populations. Science. 1976;194:23–28
- . Mutations of bacteria from virus sensitivity to virus resistance. Genetics. 1943;28:491–511
-
.
Metastasis genes: a progression puzzle.
Nature (London). 2002;418:823
- . Rules for making human tumor cells. N. Engl. J. Med. 2002;347:1593–1603
-
.
The microenvironment of the tumour–host interface.
Nature (London). 2001;411:375–379
-
.
Inflammation and cancer.
Nature (London). 2002;420:860–867
-
.
New functions for the matrix metalloproteinases in cancer progression.
Nature Rev. Cancer. 2002;2:161–174
- . The distribution of secondary growths in cancer of the breast. Lancet. 1889;1:571–573
- . Vasculogenic mimicry and tumor angiogenesis. Am. J. Pathol. 2000;156:361–381
- . Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am. J. Pathol. 1999;155:739–752
-
.
Dissecting tumour pathophysiology using intravital microscopy.
Nature Rev. Cancer. 2002;2:266–276
-
.
New human microvascular endothelial cell lines with specific adhesion molecules phenotypes.
Endothelium New York. 2002;9:247–261
-
.
A tumor-homing peptide with a targeting specificity related to lymphatic vessels.
Nature Med. 2002;8:751–755
- . Probing the structural and molecular diversity of tumor vasculature. Trends Mol. Med. 2002;8:563–571
-
.
Specialization of tumour vasculature.
Nature Rev. Cancer. 2002;2:83–90
- . Chemokines induce migrational responses in human breast carcinoma cell lines. Int. J. Cancer. 1997;71:257–266
- . Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells. Biochim. Biophys. Acta. 1982;695:113–176
-
.
Involvement of chemokine receptors in breast cancer metastasis.
Nature (London). 2001;410:50–56
- . Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 2002;62:1832–1837
-
.
Chemokine biology in cancer.
Seminars Immunol. 2003;15:49–55
- . Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev. 1995;14:279–301
- . Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res. 1995;55:2520–2523
- . Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells. Am. J. Pathol. 2003;162:403–412
-
.
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis.
Nature Med. 2000;6:100–102
-
.
Metastasis: dissemination and growth of cancer cells in metastatic sites.
Nature Rev. Cancer. 2002;2:563–572
- . Metastatic inefficiency. Adv. Cancer Res. 1990;54:159–211
- . Concepts of metastasis. Cancer Metastasis Rev. 2000;19:219–234
-
.
Selection of successive tumor lines for metastasis.
Nature New Biol. 1973;242:148–149
- . Antiangiogenesis restricted tumor dormancy. Cancer Metastasis Rev. 1996;15:241–245
- . Multistep nature of metastatic inefficiency—dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am. J. Pathol. 1998;153:865–873
- . Identification and characterization of candidate prostate cancer metastasis-suppressor genes encoded on human chromosome 17. Cancer Res. 1999;59:5483–5487
- . Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res. 2002;62:2162–2168
-
.
Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression.
Nature Med. 1995;1:149–153
- . Apoptosis: an early event in metastatic inefficiency. Cancer Res. 2001;61:333–338
- . Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 2000;60:2541–2546
-
.
Governing step of metastasis visualized in vitro.
Proc. Natl Acad. Sci. 1997;94:11573–11576
- . Visualization of GFP-expressing tumors and metastasis in vivo. Biotechniques. 2001;30:1016–1020
- . Maintaining green fluorescent protein tissue fluorescence through bone decalcification and long-term storage. Biotechniques. 2002;33:1197–1200
-
.
MDA-MB-435 human breast carcinoma metastasis to bone.
Clin. Exptl Metastasis. 2003;
in press
- . What defines a useful marker of metastasis in human cancer?. J. Natl Cancer Inst. 1999;91:1351–1353
- . A molecular signature of metastasis in primary solid tumors. Nat. Genet. 2003;33:49–54
- . Genetic alterations in primary breast cancers and their metastases—direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer. 1997;19:267–272
- . Genetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy. Cancer. 2001;91:721–726
- . A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains. Cancer Res. 2001;61:4122–4129
-
.
Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry.
Clin. Exptl Metastasis. 2002;19:319–326
- . Molecular clonality of in-transit melanoma metastasis. Am. J. Pathol. 2001;158:1371–1378
- . Microsatellite analysis in cutaneous malignant melanoma. Melanoma Res. 2002;12:577–584
- . Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. J. Natl Cancer Inst. 2001;93:1392–1400
- . Molecular genetic analysis of malignant melanomas for aberrations of the Wnt signaling pathway genes CTNNB1, APC, ICAT and BTRC. Int. J. Cancer. 2002;100:549–556
-
.
Melanoma metastasis suppression by chromosome 6: Evidence for a pathway regulated by CRSP3 and TXNIP.
Cancer Res. 2003;63
- . Molecular markers and determinants of prostate cancer metastasis. J. Cell Physiol. 2001;189:245–256
- . Genetic and epigenetic regulation of human breast cancer progression and metastasis. Endocrine-related Cancer. 1998;5:155–197
- . Metastasis-suppressor genes: a review and perspective on an emerging field. J. Natl Cancer Inst. 2000;92:1717–1730
- . Defining the biologic role of genes that regulate prostate cancer metastasis. Curr. Opin. Urol. 2001;10:397–401
- . Identification of a novel metastasis-suppressor region on human chromosome 12. Cancer Res. 1998;58:3561–3565
- . Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. J. Urol. 2003;169:1122–1133
- . Localization of prostate cancer metastasis-suppressor activity on human chromosome 17. Prostate. 1997;33:271–280
- . Genetic control of cancer metastasis. J. Natl Cancer Inst. 1990;82:166–168
-
.
Technical considerations for studying cancer metastasis in vivo.
Clin. Exptl Metastasis. 1997;15:272–306
- . Molecular mechanisms controlling human melanoma progression and metastasis. Pathobiology. 1997;65:311–330
- . Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene. 1994;9:255–262
-
.
Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23).
Clin. Exptl Metastasis. 1997;15:259–265
-
.
Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion.
Biochem. Biophys. Res. Comm. 1995;208:476–484
-
.
Metastasis-suppressed C8161 melanoma cells arrest in lung but fail to proliferate.
Clin. Exptl Metastasis. 1999;17:601–607
- . KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl Cancer Inst. 1996;88:1731–1737
-
.
Metastasis is suppressed in human melanoma cell line MelJuSo following introduction of chromosomes 1 or 6 but tumorigenicity and local invasiveness are unaffected.
Proc. Am. Assoc. Cancer Res. 1996;37:527
- . Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11. Cancer Res. 1996;56:1222–1226
- . Evidence for a novel gene associated with low tumor metastatic potential. J. Natl Cancer Inst. 1988;80:200–204
-
.
Inhibition of signal transduction by the nm23 metastasis suppressor: Possible mechanisms.
Clin. Exptl Metastasis. 2003;20:3–10
- . nm23: Unraveling its biological function in cell differentiation. J. Cell Physiol. 2000;182:144–149
-
.
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.
Proc. Natl Acad. Sci. 2001;98:4385–4390
- . Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science. 1993;261:478–480
-
.
Two-component kinase-like activity of nm23 correlates with its motility-suppressing activity.
Proc. Natl Acad. Sci. 1997;94:9000–9005
- . Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of ras via a histidine protein kinase pathway. J. Biol. Chem. 2002;277:32389–32399
- . Histidine kinases and histidine phosphorylated proteins in mammalian cell biology, signal transduction and cancer. Cancer Lett. 2003;190:1–12
- . Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition. Cancer Res. 2001;61:2320–2327
- . Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 2003;112:659–672
- . Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res. 1992;52:3486–3490
- . KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science. 1995;268:884–886
- . A family of proteins implicated in axon guidance and outgrowth. J. Neurobiol. 1999;41:158–164
- . Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res. 1996;56:4387–4390
- . KAI1, a putative marker for metastatic potential in human breast cancer. Cancer Lett. 1997;119:149–155
-
.
Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein.
Molec. Carcinog. 1998;21:111–120
- . Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells. Jpn. J. Cancer Res. 1998;89:397–404
- . Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene. 1998;16:1443–1453
- . Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage. Oncogene. 2000;19:2461–2464
-
.
The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53.
Proc. Natl Acad. Sci. 1998;95:11307–11311
- . Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines. Jpn. J. Cancer Res. 2001;92:947–951
- . Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr. Biol. 2000;10:1009–1012
- . Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. J. Cell Sci. 2002;115:433–443
-
.
Genetics and ovarian carcinoma.
Sem. Oncol. 1998;25:265–280
- . Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display. Int. J. Cancer. 1997;71:1035–1044
- . Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 1997;57:2384–2387
-
.
Identifying metastasis suppressor genes in human melanoma.
Anticancer Res. 2001;
- . The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 2001;276:34631–34636
- . AXOR12: a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J. Biol. Chem. 2001;276:28969–28975
-
.
Metastasis suppressor gene KiSS1 encodes peptide ligand of a G-protein-coupled receptor.
Nature (London). 2001;411:613–617
-
.
Metastin receptor Is overexpressed in papillary thyroid cancer and activates MAP Kinase in thyroid cancer cells.
J. Clin. Endocrin. Metab. 2002;87:2399
- . Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002;62:5399–5404
-
.
KiSS-1 represses 92
kDa type IV collagenase expression by down- regulating NFκB binding to the promoter as a consequence of IκB α-induced block of p65/p50 nuclear translocation.
J. Biol. Chem. 2001;276:1164–1172 -
.
Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.
J. Clin. Endocrin. Metab. 2002;87:5336–5339
- . Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res. 2001;61:7422–7425
- . Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. Biochim. Biophys. Acta. 1994;1219:26–32
-
.
Redox regulation of cellular activation.
Ann. Rev. Immunol. 1997;15:351–369
- . Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J. Biol. Chem. 1999;274:21645–21650
-
.
A possible interaction of thioredoxin with VDUP1 in HeLa cells detected in a yeast two-hybrid system.
Biochem. Biophys. Res. Comm. 2000;271:796–800
- . Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up- regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis. J. Neurochem. 2001;78:1267–1276
- . Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J. Immunol. 2000;164:6287–6295
-
.
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.
Proc. Natl Acad. Sci. 2002;99:11700–11705
-
.
Composite co-activator ARC mediates chromatin-directed transcriptional activation.
Nature (London). 1999;398:828–832
- . Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002;295:1058–1062
-
.
The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.
Nature (London). 1999;397:446–450
- . Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene. 2002;21:2245–2252
- . The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 2001;11:S37–S43
- . Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int. J. Cancer. 2002;97:425–431
- . Elevated serum levels of type I collagen degradation marker ICTP and tissue inhibitor of metalloproteinase (TIMP) 1 are associated with poor prognosis in lung cancer. Clin. Cancer Res. 2001;7:1633–1637
- . Simultaneous measurement of soluble carcinoembryonic antigen and the tissue inhibitor of metalloproteinase TIMP1 serum levels for use as markers of pre-invasive to invasive colorectal cancer. Cancer Immunol. Immunother. 2000;49:388–394
- . Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer—TIMP-1 as a prognostic marker. Anticancer Res. 2000;20:1311–1316
-
.
Tissue inhibitors of matrix metalloproteinases in cancer.
Ann. NY Acad. Sci. 1999;878:108–119
- . E-cadherin/catenin/cytoskeleton complex: a regulator of cancer invasion. J. Cell Physiol. 1997;173:271–274
- . Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells. Cancer Res. 1995;55:4722–4728
- . E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 1991;113:173–185
-
.
A causal role for E-cadherin in the transition from adenoma to carcinoma.
Nature (London). 1998;392:190–193
- . The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci. 1999;24:73–76
- . The E-cadherin–catenin complex in tumour metastasis: structure, function and regulation. Eur. J. Cancer. 2000;36:1607–1620
- . The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Int. J. Cancer. 2001;93:667–673
- . E-cadherin and its associated protein catenins, cancer invasion and metastasis. Br. J. Surg. 1996;83:437–446
- . E-cadherin mediated adhesion system in cancer cells. Cancer. 1996;77:1605–1613
- . Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin. Cancer Res. 2002;8:2430–2436
- . E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene. 1996;13:1919–1925
-
.
Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough.
Biochim. Biophys. Acta Rev. Cancer. 2001;1552:39–45
- . Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo. Int. J. Cancer. 2003;104:147–154
- . N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J. Cell Biol. 1999;147:631–643
- . N-Cadherin expression in human prostate carcinoma cell lines, an epithelial-mesenchymal transformation mediating adhesion with stromal cells. Am. J. Pathol. 1999;155:787–798
- . Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res. 1999;59:947–952
- . N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res. 2001;61:3819–3825
- . Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J. Cell Biol. 2000;148:779–790
- . Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res. 1997;57:4177–4182
- . Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res. 1999;59:5483–5487
- . Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Cancer Res. 2001;61:2833–2837
- . Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res. 2002;62:6717–6723
- . Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res. 2000;60:2764–2769
- . Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Exp. Cell Res. 2002;273:229–239
- . Identification and characterization of murine ortholog (Brms1) of breast cancer metastasis suppressor 1 (BRMS1). Int. J. Cancer. 2002;97:15–20
-
.
Analysis of mechanisms underlying BRMS1 suppression of metastasis.
Clin. Exptl Metastasis. 2001;18:683–693
- . Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res. 2001;61:1765–1767
-
.
Connexin and osteopontin expression correlate with breast cancer metastatic potential.
Proc. Am. Assoc. Cancer Res. 2001;42
-
.
The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines.
Clin. Exptl Metastasis. 2001;18:519–525
- . Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res. 2001;61:8866–8872
-
.
era of hope—Department of Defense Breast Cancer Research Program.
era of hope—Department of Defense Breast Cancer Research Program. Vol. 2. 2000;
p. 625
- . Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1. Mamm. Genome. 2002;13:289–292
- . A novel src- and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture. J. Biol. Chem. 1996;271:28430–28438
- . The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development. Front. Biosci. 2002;7:d1782–d1797
- . Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr. Biol. 1997;7:52–62
- . Cell-cycle regulated expression and serine phosphorylation of the myristylated protein kinase C substrate, SSeCKS: correlation with culture confluency, cell cycle phase and serum response. Mol. Cell. Biochem. 1997;175:233–241
-
.
SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)→S progression by controlling the expression and cellular compartmentalization of cyclin D.
Molec. Cell. Biol. 2000;20:7259–7272
- . The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer. Cancer Res. 2001;61:5644–5651
- . The role of Rho GTPases in disease development. Gene. 2002;286:155–174
- . RhoGD12 is an invasion and metastasis suppressor gene in human cancer. Cancer Res. 2002;62:6418–6423
- . A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab. Invest. 1997;77:85–92
- . Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 1998;58:4439–4444
- . Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res. 2000;60:749–755
-
.
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
Cancer Res. 2003;63
-
.
Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein.
Biochem. Biophys. Res. Comm. 2000;272:641–647
- . Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells. Cancer Res. 2002;62:3950–3955
- . Control of semaphorin signaling. Curr. Opin. Neurobiol. 2002;12:532–541
- . Molecular mechanisms of axon guidance. Science. 2002;298:1959–1964
- . Semaphorins as signals for cell repulsion and invasion. J. Clin. Invest. 2002;109:993–998
- . Invasive growth: from development to metastasis. J. Clin. Invest. 2002;109:857–862
-
.
A new protein containing an SH2 domain that inhibits JAK kinases.
Nature (London). 1997;387:921–924
- . Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect. Int. J. Cancer. 2001;93:773–780
- . Gelsolin: a candidate for suppressor of human bladder cancer. Cancer Res. 1995;55:3228–3232
- . Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10. Br. J. Cancer. 2003;88:606–612
- . Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science. 1994;263:526–529
- . Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model. Oncogene. 2001;20:6538–6543
- . Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene. 2002;21:4089–4098
-
.
Maspin is an angiogenesis inhibitor.
Nature Med. 2000;6:196–199
- . Role for DNA methylation in the control of cell type-specific maspin expression. Nat. Genet. 2002;31:175–179
- . Methylation matters: a new spin on maspin. Nat. Genet. 2002;31:123–124
- . p53 regulates the expression of the tumor suppressor gene maspin. J. Biol. Chem. 2000;275:6051–6054
- . Down-regulation of HP1Hs1 expression is associated with the metastatic phenotype in breast cancer. Cancer Res. 2000;60:3359–3363
- . CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13. Cancer Res. 1997;57:846–849
- . Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 1998;273:21125–21131
- . Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. Cancer Res. 1998;58:4963–4969
-
.
Metastasis suppressor genes: Basic biology and potential clinical use.
Clin. Breast Cancer. 2003;
in press
-
.
The emerging role for the mRNA cap-binding protein, EIF-4E, in metastatic progression.
In:
Welch DR editors. Cancer Metastasis: Biology and Treatment. Dordrecht: Kluwer Academic Publishers; 2002;p. 257–278
-
.
Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs.
Clin. Exptl Metastasis. 2003;20:265–273
- . DNA methylation imprinting and cancer. Eur. J. Hum. Genet. 2002;10:6–16
-
.
Cancer epigenomics.
Hum. Molec. Genet. 2002;11:2479–2488
- . Modifications of the histone N-terminal domains, evidence for an epigenetic code?. Mol. Biotechnol. 2001;17:1–13
- . Reactivating the expression of methylation silenced genes in human cancer. Oncogene. 2002;21:5496–5503
- . Histone deacetylase inhibitors: from target to clinical trials. Expert Opin. Investig. Drugs. 2002;11:1695–1713
- . Life and death by p53. BioEssays. 1995;17:923–930
- . Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002;62:2478–2482
-
.
Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor expression in metastatic human breast carcinoma cells via glucocorticoid receptor-dependent, transcriptional and post-transcriptional mechanisms: new uses for old compounds, Clin.
Cancer Res. 2003;
in press
- . Novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1. Mol. Cell. Biol. 1998;18:4577–4588
- . Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. Oncogene. 2002;21:1812–1822
- . A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines, cDNA cloning, expression, and protein analyses. J. Biol. Chem. 1994;269:22958–22963
-
.
Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation.
Clin. Exptl Metastasis. 2003;20:19–24
PII: S0304-3835(03)00304-5
doi: 10.1016/S0304-3835(03)00304-5
© 2003 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Cancer Letters
Volume 198, Issue 1
, Pages 1-20
, 30 July 2003
