Cancer Letters
Volume 198, Issue 1 , Pages 1-20, 30 July 2003

Metastasis suppressor pathways—an evolving paradigm

  • Lalita A. Shevde

      Affiliations

    • Department of Pathology, 1670 University Boulevard, Volker Hall - G-038, The University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
    • ,
  • Danny R. Welch

      Affiliations

    • Department of Pathology, 1670 University Boulevard, Volker Hall - G-038, The University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
    • UAB-Comprehensive Cancer Center, The University fo Alabama at Birmingham, Birmingham, AL 35294, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Pathology, 1670 University Boulevard, Volker Hall -G-038, The University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA. Tel.: +1-205-934-4612; fax: +1-205-934-1775

Received 5 April 2003; accepted 16 April 2003.

Abstract 

A greater understanding of the processes of tumor invasion and metastasis, the principal cause of death in cancer patients, is essential to determine newer therapeutic targets. Metastasis suppressor genes, by definition, suppress metastasis without affecting tumorigenicity and, hence, present attractive targets as prognostic or therapeutic markers. This short review focuses on those twelve metastasis suppressor genes for which functional data exist. We also outline newly identified genes that bear promising traits of having metastasis suppressor activity, but for which functional data have not been completed. We also summarize the biochemical mechanism(s) of action (where known), and present a working model assembling potential metastasis suppression pathways.

Keywords: Metastasis, Suppression, Genes, Cancer, Tumor, Tumorigenesis, KISS1, MKK4, BRMS1, CRSP3, TXNIP, E-cadherin, CRMP1, Maspin, CD44, SSeCKS, Nm23, KAI1, TIMPs, DRG-1, Metastin, Multigene, Invasion, Prognosis, Therapeutic, Marker, Target, Anoikis, Proliferation, Apoptosis, Angiogenesis, Neovascularisation

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PII: S0304-3835(03)00304-5

doi:10.1016/S0304-3835(03)00304-5

Cancer Letters
Volume 198, Issue 1 , Pages 1-20, 30 July 2003

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