Cancer Letters
Volume 198, Issue 1 , Pages 37-42 , 30 July 2003

Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori

  • Midori Takasaki

      Affiliations

    • Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-75-595-4645; fax: +81-75-595-4754
    • ,
  • Takao Konoshima

      Affiliations

    • Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
    • ,
  • Yuji Murata

      Affiliations

    • Biochemical Laboratory, Saraya Co., LTD, Higashisumiyoshi-ku, Osaka 546-0013, Japan
    • ,
  • Masaki Sugiura

      Affiliations

    • Biochemical Laboratory, Saraya Co., LTD, Higashisumiyoshi-ku, Osaka 546-0013, Japan
    • ,
  • Hoyoku Nishino

      Affiliations

    • Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, Japan
    • ,
  • Harukuni Tokuda

      Affiliations

    • Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-0841, Japan
    • ,
  • Kazuhiro Matsumoto

      Affiliations

    • Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan
    • ,
  • Ryoji Kasai

      Affiliations

    • Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan
    • ,
  • Kazuo Yamasaki

      Affiliations

    • Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan

Received 20 February 2002 ,Revised 2 April 2003 ,Accepted 7 April 2003.

References 

  1. Takasaki M, Konoshima T, Kuroki S, Tokuda H, Nishino H. Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium. Cancer Lett. 2001;173:133–138
  2. Takasaki M, Konoshima T, Etoh H, Singh IP, Tokuda H, Nishino H. Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis. Cancer Lett. 2000;155:61–65
  3. Konoshima T, Takasaki M, Tokuda H, Nishino H. Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens. Cancer Lett. 2000;157:87–92
  4. Konoshima T, Takasaki M. Cancer chemopreventive effects of natural sweeteners and related compounds. Pure Appl. Chem. 2002;74:1309–1316
  5. Kasai R, Matsumoto K, Nie RL, Morita T, Awazu A, Zhou J, et al. Sweet and bitter cucurbitane glycosides from Hemsleya carnosiflora. Phytochemistry. 1987;26:1371–1376
  6. Kasai R, Matsumoto K, Nie RL, Zhou J, Tanaka O. Glycosides from Chinese medicinal plants, Hemsleya panacis-scandens and structure–taste relationship of cucurbitane glycosides. Chem. Pharm. Bull. 1988;36:234–243
  7. Matsumoto K, Kasai R, Ohtani K, Tanaka O. Minor cucurbitane glycosides from fruits of Momordica grosvenori (Cucurbitaceae). Chem. Pharm. Bull. 1990;38:2030–2032
  8. Takeo E, Yoshida H, Tada N, Shingu T, Matsuura H, Murata Y, et al. Sweet elements of Siraitia (Momordica) grosvenori inhibit oxidative modification of low density lipoprotein. J. Atherosclerosis Thromb. 2002;9:114–120
  9. Tokuda H, Ichiishi E, Onozuka M, Yamaguchi S, Konoshima T, Takasaki M, et al. The tumor initiating activity of NO donor. In:  Moncada S,  Tada N,  Maeda H,  Higgs EA editor. Biology of Nitric Oxide. London: Portland Press; 1998;p. 185–186 Part 6
  10. Konoshima T, Takasaki M, Ichiishi E, Tokuda H, Nishino H, Duc NM, et al. Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis. Cancer Lett. 1999;147:11–16
  11. Konoshima T, Takasaki M, Tokuda H, Morimoto S, Tanaka H, Kawata E, et al. Crocin and crocetin derivatives inhibit skin tumor promotion in mice. Phytother. Res. 1998;12:400–404
  12. Takasaki M, Konoshima T, Tokuda H, Masuda K, Arai Y, Shiojima K, et al. Anti-carcinogenic activity of Taraxacum plant (1). Biol. Pharm. Bull. 1999;22:602–605
  13. Takasaki M, Tokuda H, Nishino H, Konoshima T. Cancer chemopreventive agents (Anti-tumor-promoters) from Ajuga decumbens. J. Nat. Prod. 1999;62:972–975
  14. Takasaki M, Konoshima T, Komatsu K, Tokuda H, Nishino H. Cancer chemopreventive activity of lignans from the aerial part of Saussurea medusa. Cancer Lett. 2000;158:53–59
  15. Chakrabarty A, Brantner T, Mukainaka Y, Nobukuni M, Kuchide T, Konoshima H, et al. Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Lett. 2002;177:13–16

PII: S0304-3835(03)00285-4

doi: 10.1016/S0304-3835(03)00285-4

Cancer Letters
Volume 198, Issue 1 , Pages 37-42 , 30 July 2003

Article Tools

* Image Usage & Resolution