Cancer Letters
Volume 194, Issue 2 , Pages 183-188, 15 May 2003

Telomeres in cancer and aging: lessons from the mouse

Department of Immunology and Oncology, National Centre of Biotechnology, E-28049 Madrid, Spain

Received 5 August 2002; received in revised form 15 October 2002; accepted 16 October 2002.

Abstract 

The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively.

Telomere, Telomerase, TERC, TERT, DNA repair, Cancer, Aging, Knockout, Mouse model, Telomere capping, Tumorigenesis, Transformation, Tumor

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PII: S0304-3835(02)00705-X

doi:10.1016/S0304-3835(02)00705-X

Cancer Letters
Volume 194, Issue 2 , Pages 183-188, 15 May 2003

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