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Cancer Letters
Volume 194, Issue 2
, Pages 173-182
, 15 May 2003
Telomere-driven genomic instability in cancer cells
References
- . Telomerase activity in small-cell and non-small-cell lung cancers. J. Natl. Cancer Inst. 1995;87:895–902
- . Telomerase activity in gastric cancer. Cancer Res. 1995;55:3258–3262
- . Telomere loss: mitotic clock or genetic time bomb ?. Mutat. Res. 1991;256:271–282
- . Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458–460
- . Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 1999;97:515–525
- . TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene. 2002;21:3130–3138
- . Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 2000;20:1659–1668
- . Protection of mammalian telomeres. Oncogene. 2002;21:532–540
- . Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J. Biol. Chem. 2001;276:29282–29291
-
.
Ku is associated with the telomere in mammals.
Proc. Natl. Acad. Sci. USA. 1999;96:12454–12458
-
.
DNA-PKcs is critical for telomere capping.
Proc. Natl. Acad. Sci. USA. 2001;98:15084–15088
-
.
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes.
Proc. Natl. Acad. Sci. USA. 1999;96:14899–14904
- . Switching and signaling at the telomere. Cell. 2001;106:661–673
- . Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell. 2002;2:149
- . Connecting chromosomes, crisis, and cancer. Science. 2002;297:565–569
- . Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997;91:25–34
- . Elongated telomeres in scid mice. Genomics. 1999;56:221–223
- . A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr. Opin. Genet. Dev. 2000;10:39–46
- . Telomere dysfunction increases mutation rate and genomic instability. Cell. 2001;106:275–286
-
.
Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.
Proc. Natl. Acad. Sci. USA. 2001;98:12683–12688
- . A survey of telomerase activity in human cancer. Eur J Cancer. 1997;33:787–791
- . Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat. Med. 1997;3:1271–1274
- . Chromosome alterations in cancer development and apoptosis. In Vivo. 1994;8:843–850
-
.
Telomerase activity in normal and malignant hematopoietic cells.
Proc. Natl. Acad. Sci. USA. 1995;92:9082–9086
- . Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349–352
- . Chromosome healing: spontaneous and programmed de novo telomere formation by telomerase. Bioessays. 1996;18:301–308
-
.
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.
Proc. Natl. Acad. Sci. USA. 1999;96:3723–3728
-
.
Telomerase contributes to tumorigenesis by a telomere length- independent mechanism.
Proc. Natl. Acad. Sci. USA. 2002;99:12606–12611
- . Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell. Biol. 2001;21:3862–3875
- . Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp. Cell Res. 2000;256:291–299
- . Telomere dynamics in an immortal human cell line. EMBO J. 1994;13:4953–4962
- . An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell. 1993;73:347–360
-
.
Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process.
Mol. Cell. 2000;6:947–952
- . Telomere maintenance by recombination in human cells. Nat. Genet. 2000;26:447–450
- . Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol. Cell. Biol. 2001;21:1819–1827
- . Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Mol. Cell. Biol. 2001;21:2048–2056
- . Mammalian telomeres end in a large duplex loop. Cell. 1999;97:503–514
- . Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts. Oncogene. 1998;17:709–717
- . Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Oncogene. 2001;20:3835–3844
-
.
Chromosome healing in mouse embryonic stem cells.
Proc. Natl. Acad. Sci. USA. 1999;96:6781–6786
- . Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J. 2001;20:2619–2630
- . Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 1999;59:4175–4179
- . A repressor function for telomerase activity in telomerase-negative immortal cells. Mol. Carcinog. 1998;21:17–25
- . Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat. Genet. 2000;26:85–88
- . Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp. Cell Res. 1998;239:152–160
-
.
DNA damage and repair in telomeres: relation to aging.
Proc. Natl. Acad. Sci. USA. 1995;92:258–262
- . Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J. Exp. Med. 2000;192:1625–1636
- . Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res. 2001;61:912–915
- . Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res. 2001;61:912–915
- . Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies. Am. J. Hum. Genet. 1998;63:297–304
- . Alternative lengthening of telomeres in mammalian cells. Oncogene. 2002;21:598–610
- . The transcriptional role of PML and the nuclear body. Nat. Cell Biol. 2000;2:E85–E90
- . p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323–331
- . The cellular response to p53: the decision between life and death. Oncogene. 1999;18:6145–6157
- . Chromosome instability is a predominant trait of fibroblasts from Li- Fraumeni families. Br. J. Cancer. 1998;77:2181–2192
- . Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein. Oncogene. 1998;16:1825–1838
- . Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell Biol. 2001;13:332–337
-
.
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
Proc. Natl. Acad. Sci. USA. 1994;91:413–417
- . Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell. 1995;81:1021–1029
- . p53 binds telomeric single strand overhangs and t-loop junctions in vitro. J. Biol. Chem. 2002;277:11625–11628
- . TRF2 protects human telomeres from end-to-end fusions. Cell. 1998;92:401–413
- . DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr. Biol. 2002;12:1635
- . The relationship between spontaneous telomere loss and chromosome instability in a human tumor cell line. Neoplasia. 2000;2:540–554
- . Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 1992;11:2665–2673
-
.
DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.
Neoplasia. 2002;4
- . Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol. Cell. Biol. 1993;13:977–983
- . Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol. Cell. Biol. 2002;22:4836–4850
-
.
Mechanisms underlying losses of heterozygosity in human colorectal cancers.
Proc. Natl. Acad. Sci. USA. 2001;98:2698–2702
- . Telomeric and nontelomeric (TTAGGG)n sequences in gene amplification and chromosome stability. Genomics. 1994;24:53–62
- . Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J. Exp. Med. 2002;196:469–480
- . Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants. Carcinogenesis. 2001;22:141–145
- . Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit. Cancer Res. 2001;61:4520–4525
- . Relationship of DNA lesions and their repair to chromosomal aberration production. Basic Life Sci. 1980;15:245–265
- . The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations. Mutat. Res. 1986;160:231–236
- . Hypertonic treatment during premature chromosome condensation allows visualization of interphase chromosome breaks repaired with fast kinetics in irradiated CHO cells. Radiat. Res. 1993;135:160–170
- . Possible role of chromatin alteration in the radiosensitivity of ataxia- telangiectasia. Int. J. Radiat. Biol. 1994;66:S109–S113
- . Yeast Ku as a regulator of chromosomal DNA end structure. Science. 1998;280:741–744
- . Biased distribution of inverted and direct Alus in the human genome: implications for insertion, exclusion, and genome stability. Genome Res. 2001;11:12–27
- . Non-homologous recombination between Alu and LINE-1 repeats caused a 430-kb deletion in the dystrophin gene: a novel source of genomic instability. J. Hum. Genet. 2000;45:331–336
- . Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer. 1999;24:48–55
- . Role for CCG-trinucleotide repeats in the pathogenesis of chronic lymphocytic leukemia. Blood. 2001;97:509–515
- . Deletion of the short arm of chromosome 3 in breast tumors. Genes Chromosomes Cancer. 1997;18:241–245
- . Molecular characterization of a pericentric inversion in mouse chromosome 8 implicates telomeres as promoters of meiotic recombination. Chromosoma. 1993;102:112–120
- . Instability of interstitial telomeric sequences in the human genome. Genomics. 2000;68:111–117
- . DNA repeats in the human genome. Genetica. 1999;106:15–36
- . Simple repetitive sequences in the genome: structure and functional significance. Electrophoresis. 1995;16:1705–1714
- . Chromosomal radiosensitivity at intrachromosomal telomeric sites. Genes Chromosomes Cancer. 1993;8:8–14
- . Spontaneous and radiation-induced chromosomal breakage at interstitial telomeric sites. Chromosoma. 1996;104:596–604
-
.
Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations.
Proc. Natl. Acad. Sci. USA. 2001;98:13300–13305
- . Chromosome regions enriched in hyperacetylated histone H4 are preferred sites for endonuclease- and radiation-induced breakpoints. Chromosome Res. 2001;9:69–75
- . A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin. Cell. 1983;32:1191–1203
- . Radiation-induced chromosomal breakage and rejoining in interphase- metaphase chromosomes of human lymphocytes. Mutat. Res. 1991;249:29–35
- . Distribution of X-ray-induced G2 chromatid damage among Chinese hamster chromosomes: influence of chromatin conformation. Mutat. Res. 1994;323:113–119
- . Distribution of radiation-induced G1 exchange and terminal deletion breakpoints in Chinese hamster chromosomes as detected by G banding. Int. J. Radiat. Biol. 1994;66:747–755
- . Localization of chromosome breakpoints: implication of the chromatin structure and nuclear architecture. Mutat. Res. 1998;404:17–26
- . Localization of radiation-induced chromosomal breakpoints along human chromosome 1 using a combination of G-banding and FISH. Int. J. Radiat. Biol. 2000;76:667–672
- . The Mre11 complex is required for repair of hairpin-capped double- strand breaks and prevention of chromosome rearrangements. Cell. 2002;108:183–193
- . NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases. Nucleic Acids Res. 1998;26:4078–4085
- . Evidence of a differential organization of chromatin containing terminal or interstitial (TTAGGG)n repeats by in situ digestion with nucleases. Cytogenet. Cell Genet. 1998;82:195–198
- . Immunofluorescent analysis of the organization of telomeric DNA sequences and their involvement in chromosomal aberrations in hamster cells. Mutat. Res. 1996;372:163–172
- . A negative regulator of telomere-length protein trf1 is associated with interstitial (TTAGGG)n blocks in immortal Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 2001;280:471–475
- . Molecular cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability. Oncogene. 1998;17:2137–2142
- . Length of uninterrupted repeats determines instability at the unstable mouse expanded simple tandem repeat family MMS10 derived from independent SINE B1 elements. Mamm. Genome. 2001;12:104–111
- . Co-localisation of CCG repeats and chromosome deletion breakpoints in Jacobsen syndrome: evidence for a common mechanism of chromosome breakage. Hum. Mol. Genet. 2000;9:1201–1208
- . Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved ‘chromatin folding code’. Hum. Genet. 1990;84:301–336
PII: S0304-3835(02)00704-8
doi: 10.1016/S0304-3835(02)00704-8
© 2003 Elsevier Science Ireland Ltd. All rights reserved.
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Cancer Letters
Volume 194, Issue 2
, Pages 173-182
, 15 May 2003
