Cancer Letters
Volume 194, Issue 2 , Pages 137-138 , 15 May 2003

Telomeres, telomerase and the cancer cell: an introduction

Received 30 October 2002 ,Accepted 30 October 2002.

References 

  1. Muller HJ. The remaking of chromosomes. Collecting Net. 1938;8:182–195
  2. McClintock B. The stability of broken ends of chromosomes in Zea mays. Genetics. 1941;26:234–282
  3. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458–460
  4. Watson JD. Origin of concatemeric DNA. Nat. New Biol. 1972;239:197–201
  5. Olovnikov AM. A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the problem. J. Theor. Biol. 1973;41:181–190
  6. Greider C, Blackburn EH. Identification of a specific terminal transferase activity in Tetrahymena extracts. Cell. 1985;51:887–898
  7. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349–352
  8. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 2002;27:339–344
  9. Gorbunova V, Seluanov A, Pereira-Smith OM. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J. Biol. Chem. 2002;277:38540–38549
  10. Blackburn EH. Telomere states and cell fates. Nature. 2000;408:53–56
  11. von Zglinicki T. Telomeres and replicative senescence: Is it only length that counts?. Cancer Lett. 2001;168:111–116

PII: S0304-3835(02)00700-0

doi: 10.1016/S0304-3835(02)00700-0

Cancer Letters
Volume 194, Issue 2 , Pages 137-138 , 15 May 2003