Cancer Letters
Volume 172, Issue 2 , Pages 193-198, 30 October 2001

Effects of Maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis

Department of Microbial chemistry, Kobe Pharmaceutical University, 19-1, Motoyama-kitamachi 4-chome, Higashinada-ku, Kobe 658-8558, Japan

Received 30 May 2001; received in revised form 18 June 2001; accepted 22 June 2001.

Abstract 

We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D-Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-α production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction.

Keywords:  Angiogenesis, Anti-tumor activity, Maitake D-Fraction

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PII: S0304-3835(01)00652-8

doi:10.1016/S0304-3835(01)00652-8

Cancer Letters
Volume 172, Issue 2 , Pages 193-198, 30 October 2001

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