Review letterWhey proteins in cancer prevention
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Cited by (83)
Whey protein in cancer therapy: A narrative review
2019, Pharmacological ResearchCitation Excerpt :More recent research [85] in animal models has confirmed this hypothesis with rats fed whey (0.334 g/kg) that displayed an increase in liver GSH (+92%) and a decrease in tumor GSH (-47%). These findings suggest, as initially proposed by Bounous et al., that whey protein may be a promising strategy to overcome treatment resistance in cancer therapy [78]. In rodents, a diet with 20 g of whey protein per 100 g/body weight raised the degree of protection against intestinal cancer induced by 1,2-dimethylhydrazine when comparing with a control group consuming the same amount of protein from soy or red meat [86].
Whey proteins in functional foods
2018, Whey Proteins: From Milk to MedicineSurface plasmon resonance based spectrophotometric determination of medicinally important thiol compounds using unmodified silver nanoparticles
2017, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyCitation Excerpt :Investigation of the interaction of nanoparticles [8–12] with biologically relevant and medicinally important thiol-containing molecule such as cysteine (Cys), lipoic acid, and mesna (Scheme 1) is crucial for the development of colorimetric sensor. These molecules are found to play pivotal roles in a variety of diseases such as diabetes, liver damage, mild cognitive impairment, pneumonia, rheumatoid arthritis, AIDS, Cancer and other serious diseases [13–23]. Therefore, it is crucial to develop a sensitive, accurate and simple method for detection of these molecules.
Benefits of whey proteins on human health
2017, Dairy in Human Health and Disease across the LifespanBiochemical and clinical effects of Whey protein supplementation in Parkinson's disease: A pilot study
2016, Journal of the Neurological SciencesAntioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells
2014, International Dairy JournalCitation Excerpt :Dietary whey protein, presumably due to its high level of cysteine, has been shown to increase the production of cellular glutathione in elderly patients with acute ischaemic stroke (de Aguilar-Nascimento, Prado Silveira, & Dock-Nascimento, 2011) and in patients with advanced HIV infection (Micke, Beeh, & Buhl, 2002). Different studies have reported anti-cancer effects associated with the consumption of whey proteins which resulted in an increase in cellular GSH levels (Bounous, Batist, & Gold, 1991; McIntosh, Regester, Leleu, Royle, & Smithers, 1995). Furthermore, previous studies have shown increases in cellular GSH levels following incubation of human Jurkat T cells with casein hydrolysates (Phelan, Aherne-Bruce, O'Sullivan, FitzGerald, & O'Brien, 2009) and incubation of HUVECs with isoflavonoids (Guo, Rimbach, Moini, Weber, & Packer, 2002).
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Professor of Surgery, McGill University, and Career Investigator of The Medical Research Council of Canada.
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Director, Experimental Therapeutics, Department of Oncology, McGill University.