Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of solasodine glycosides
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Cited by (63)
Cytotoxic and chemosensitizing effects of glycoalkaloidic extract on 2D and 3D models using RT4 and patient derived xenografts bladder cancer cells
2021, Materials Science and Engineering CTargeted uptake of folic acid-functionalized polymeric nanoparticles loading glycoalkaloidic extract in vitro and in vivo assays
2020, Colloids and Surfaces B: BiointerfacesSolasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression
2017, Chemico-Biological InteractionsCitation Excerpt :Solasodine is an aglycone of solamargine and solasonine, which are the major solasodine glycosides present in eggplant (Solanum melongena) [1]. Previous studies have shown that solasodine glycosides exhibit anticancer activity against skin cancer [2,3]. Solamargine and solasonine are effective in inhibiting the growth of human tumor cell lines such as colon, liver, lung and breast cancer cell lines [1,4,5].
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2016, Advances in Potato Chemistry and TechnologyIn vitro and in vivo evaluation of the delivery of topical formulations containing glycoalkaloids of Solanum lycocarpum fruits
2014, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :However, the efficacy of these compounds not only depends on the quantity used but also on the composition of the topical formulation. For instance, cetomacrogol-based cream with 10% glycoalkaloids and 10% dimethylsulfoxide (DMSO) effected an 83% skin carcinoma cure rate [16], while another formulation with 0.005% glycoalkaloids and keratolytic agents was 100% curative [20]. In contrast, a 66% cure rate was achieved with 0.005% glycoalkaloids and keratolytic agents in emulsifying wax and white soft paraffin base [17].
Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro
2013, Journal of EthnopharmacologyCitation Excerpt :Compounds 1 and 2 are similar in structure to the steroidal glycoalkaloids, α-solamargine and α-solasonine, found in solanceaous plants. These compounds have been successfully used in the treatment of human skin carcinomas (Cham et al., 1991). Consistent with the structure–cytotoxicity relationship observed for steroidal saponins against HL-60 human promyelocytic leukemia cells (Mimaki et al., 2001), steroidal glycoalkaloids 1 and 2, sharing the same aglycone and only differing in the carbohydrate moiety, exhibited differential cytotoxicity.