Current Issue 28 March 2012, Vol. 316, No. 2

Issue Highlights

SUMOylation in carcinogenesis
28 March 2012(Vol. 316 | No. 2 | Pages 113-125)
Kira Bettermann, Martin Benesch, Serge Weis, Johannes Haybaeck

Intussusceptive microvascular growth in tumors
28 March 2012(Vol. 316 | No. 2 | Pages 126-131)
Domenico Ribatti, Valentin Djonov

Lipocalin 2 in cancer: When good immunity goes bad
28 March 2012(Vol. 316 | No. 2 | Pages 132-138)
Jeffrey J. Rodvold, Navin R. Mahadevan, Maurizio Zanetti

Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways
24 January 2012
Zhenbo Zhang, Dongmei Zhou, Yunli Lai, Yongjuan Liu, Xiang Tao, Qianqian Wang, Guixu Zhao, Hongqin Gu, Hong Liao, Yaping Zhu, Xiaowei Xi, Youji Feng
Abstract: Obesity is generally acknowledged as a risk factor for endometrial cancer, as accumulated adipocytes partly contribute to the increased production of estrogen which is involved in dysregulat...
Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
24 January 2012
Yasuo Harada, Isao Ishii, Kiyohiko Hatake, Tadashi Kasahara
Abstract: Pyrvinium pamoate (PP), a classical anthelminthic, potently inhibited proliferation and STAT3 Tyr705 phosphorylation of human myeloma (U266B1 and PCM6)/erythroleukemia (HEL 92.1.7) cells. PC...
CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes
24 January 2012
Bianca Mostert, Jaco Kraan, Anieta M. Sieuwerts, Petra van der Spoel, Joan Bolt-de Vries, Wendy J.C. Prager-van der Smissen, Marcel Smid, Annemieke M. Timmermans, John W.M. Martens, Jan W. Gratama, John A. Foekens, Stefan Sleijfer
Abstract: Circulating tumor cells (CTCs) can be enumerated using CellSearch, but not all breast cancer subtypes, specifically those with epithelial-mesenchymal transition (EMT) characteristics, suffic...
Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation
24 January 2012
Shengtao Zhou, Yuhua Li, Fuqiang Huang, Boya Zhang, Tao Yi, Zhengyu Li, Hong Luo, Xiang He, Qian Zhong, Ce Bian, Xiaojuan Lin, Xiaorong Qi, Ping Liu, Canhua Huang, Xia Zhao, Yuquan Wei
Abstract: Herein we present a novel molecular mechanism of the antitumor effects of live-attenuated measles virus (MV) vaccine in ovarian cancer. Using a 2-DE/MS-based comparative proteomics strategy,...
BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
24 January 2012
Victoria Del Gaizo Moore, Anthony Letai
Abstract: Apoptosis is a form of programmed cell death that is controlled at the mitochondrion by the BCL-2 family of proteins. While much has been learned about the structure and function of these pr...

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Arun Satelli, U. Subrahmanyeswara Rao
Combined targeting of the VEGFr/EGFr and the mammalian target of rapamycin (mTOR) signaling pathway delays cell cycle progression and alters adhesion behavior of prostate carcinoma cells
1 February 2011 (Vol. 301 | No. 1 | Pages 17-28)
Steffen Wedel, Lukasz Hudak, Jens-Michael Seibel, Eva Juengel, Igor Tsaur, Axel Haferkamp, Roman A. Blaheta
DNA methylation in thoracic neoplasms
1 February 2011 (Vol. 301 | No. 1 | Pages 7-16)
Chen Chen, Ni Yin, Bangliang Yin, Qianjin Lu
DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway
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About Cancer Letters

Cancer Letters is an international journal that considers full-length articles and Mini Reviews in the broad area of basic and translational oncology. Additionally, Special Issues highlight topical areas in cancer research. Basic areas of interest to a broad readership of Cancer Letters include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal places emphasis on experimental therapeutics, particularly targeted therapies for personalized cancer medicine.