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Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors
18 May 2012
Nam-Chul Jung, Hee Jung Kim, Mi-Sun Kang, Jun-Ho Lee, Jie-Young Song, Han Geuk Seo, Yong-Soo Bae, Dae-Seog Lim
Abstract: Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged ...
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Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo
17 May 2012
Senay Yildirim, Seyhan Altun, Hatice Gumushan, Anup Patel, Mustafa B.A. Djamgoz
Abstract: Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggest...
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Statins and cancer: Current and future prospects
17 May 2012
Maja Osmak
Abstract: Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects beyond cholesterol reduction, including anticancer activity. This review presents the effects of ...
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Translating TRAIL-receptor targeting agents to the clinic
17 May 2012
Martha W. den Hollander, Jourik A. Gietema, Steven de Jong, Annemiek M.E. Walenkamp, Anna K.L. Reyners, Corina N.A.M. Oldenhuis, Elisabeth G.E. de Vries
Abstract: The extrinsic apoptotic pathway can be activated by the endogenous ligand TRAIL (Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand) by binding to the death receptors TRAIL-R1 and...
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Epigenetics in human gliomas
16 May 2012
Simone Kreth, Niklas Thon, Friedrich W. Kreth
Abstract: Aberrant epigenetic landscapes and their involvement in genesis and progression of tumors, as well as in treatment responses and prognosis, indicate one of the most emerging fields in cancer...
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